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Proactazyme is a fullspectrum enzyme supplement formulated to improve digestion and nutrient absorption from food. Proactazyme contains plantbased enzymes that effectively break down proteins, starches, sugars, fats and plant fiber. Proactazyme also provides a blend of herbs and nutrients that have been shown to increase the body’s production of salivary and digestive fluids and enhance liver and gallbladder function to promote optimal digestion. 

Enzyme supplementation is an established method of treatment for a number of digestive conditions. Digestive enzyme supplementation can help break down proteins, fats and carbohydrates and may benefit health problems involving compromised digestion. Recent research has shown that digestive enzyme supplementation may also help relieve some of the symptoms of irritable bowel syndrome, such as abdominal pain, bloating and flatulence (intestinal gas). Enzymes also aid in the elimination of toxins, including potentially harmful allergens and environmental pollutants. Unless obtained in the diet (from raw fruits and vegetables or dietary supplements), the constant demands on the body to manufacture enzymes can cause enzyme deficiency—a common problem that can lead to digestive dysfunction, obesity, cancer, cardiovascular disease and other illnesses.1-6 

Each capsule of Proactazyme contains: 

Potassium citrate is an alkaline salt used in enzyme supplements to help maintain an optimal pH range, which facilitates enzyme activity. In addition, a recent study found that potassium citrate reduced bone resorption (boneloss), thereby combating the potential adverse effects of chronic acidemia (an overacid condition) caused by proteinrich diets.3,7,8 

Proteases (proteolytic enzymes) break down proteins into single amino acids that can be absorbed by the body. Proteases digest protein at the rate of up to 300 grams per hour. Research also shows that proteases are largely responsible for keeping the small intestine free of parasites, including bacteria, intestinal worms, protozoa and yeast. Thus, a lack of protease can greatly increase the chances of intestinal infection, including the overgrowth of the yeast Candida albicans. Protease 3.0 breaks down most soluble proteins in the stomach; Protease 4.5 facilitates protein digestion in the stomach and pyloric regions of the small intestine; and, Protease 6.0 digests proteins throughout the digestive tract.3,9-18 

Amylase breaks down glycogen, starches and the majority of other carbohydrates into smaller carbohydrate molecules, also referred to as simple sugars. Amylase facilitates the digestion of highstarch foods, including white breads, pasta and potatoes. Supplemental amylase may be helpful for reducing sugar cravings and raising low blood sugar levels.3,18-26 

Glucoamylase breaks down carbohydrates (particularly starches that occur in high amounts in corn, potatoes and rice) into glucose in the small intestine. A deficiency of glucoamylase can result in digestive problems, including gas, bloating and diarrhea following the ingestion of starches.9,25,26,2729 

Lipase is a digestive enzyme that breaks down fat (lipids), including triglycerides (fats and oils), phospholipids (such as lecithin), and sterols (such as cholesterol). Lipase improves fat digestion and utilization, helps reduce cholesterol, and supports hormone production and gallbladder function. Bile, which is stored in the gallbladder, also helps emulsify fats and enables lipase to digest fats more efficiently. Sufficient levels of lipase and bile salts are required for proper absorption of fatsoluble vitamins (e.g. vitamins A, D, E and K).3,18,2022,30,31 

Cellulase is an enzyme that breaks down cellulose (the otherwise indigestible fiber found in fruits and vegetables), as well as cereal glucans, thus enabling additional nutrients to be released from the plant fiber. Cellulase is also used as a digestive aid to help reduce the bulking effect of fibrous foods and prevent flatulence.3,9,18,3234 

Invertase breaks down carbohydrates, particularly sucrose (table sugar), into fructose and glucose. Invertase enhances the digestion of refined sugars and may be helpful as a digestive aid for those who have trouble digesting sugars.9,18,35 

Malt Diastase works with amylase and glucoamylase to break down carbohydraterich foods, especially those produced from grains, in the small intestine.9,18,27 

AlphaGalactosidase breaks down the complex sugars (oligosaccharides) present in legumes and cruciferous vegetables, including beans, broccoli, brussels sprouts, cabbage, cauliflower and peas. When not properly digested, these sugars remain in the digestive tract where they ferment, causing bloating and intestinal gas. A doubleblind study confirmed that supplementation with alphaGalactosidase significantly reduced intestinal gas production following ingestion of cooked beans. Additional research suggests that alphaGalactosidase supplementation may help reduce the gasrelated symptoms caused by naturallyoccurring oligosaccharides in soy milk.9,32,36,37 

Peptidase, a proteolytic enzyme, is responsible for the final step in protein digestion, which takes place in the small intestine. It is important to note that zinc deficiency decreases peptidase activity, thus affecting protein digestion and absorption.19,38-40 

Beet root contains betaine, which exerts a positive effect on fat metabolism in the liver. Beet root is also an excellent source of pectin, a soluble dietary fiber. Beet root fiber has been shown to reduce serum cholesterol levels and improve gut health in animal studies.41-45 

Caraway seed is approved by the German Commission E for dyspeptic complaints (indigestion), and is also used for gastrointestinal cramps, flatulence, feelings of fullness, and sluggish digestion. Caraway seed aids digestion by stimulating the release of digestive enzymes and by soothing the lining of the gastrointestinal tract. In addition, caraway seed contains a volatile oil that has been shown to have antimicrobial effects against bacteria that can cause foodborne illnesses (e.g. Escherichia coli, Staphylococcus aureus).41,46-50 

Dandelion root contains an abundance of bitter substances that increase gastric and salivary juice secretions and stimulate the release of bile from the gallbladder and liver to promote healthy digestion. Dandelion root is approved by the German Commission E for dyspepsia (indigestion) and bile flow problems.41,48,5154 

Fennel seed is approved by the German Commission E for digestive disorders such as bloating, dyspepsia and flatulence, as well as mild, spastic or cramping gastrointestinal complaints (e.g. spastic colon, also known as irritable bowel syndrome). Fennel seed increases bile production and regulates the peristaltic functions of the gastrointestinal tract, thereby enhancing gastric motility and increasing the passage of intestinal gas.41,46,48,51,52,54-56 

Gentian root is approved by the German Commission E for digestive disorders related to insufficient production of gastric juices, such as flatulence and feelings of fullness. The active principles in gentian are bitter substances that promote increased secretion of saliva and digestive juices, as well as bile, which helps emulsify fats.30,46-48,51,54 

Ginger root contains various compounds that act as digestive stimulants, enhancing gall bladder activity and encouraging the production of digestive fluids and saliva. Animal studies have confirmed that ginger enhances the secretion of bile salts and stimulates pancreatic lipase activity, thus enhancing the digestion of fats. Ginger also improves gastric motility (movement through the digestive tract), while exerting antispasmodic (musclerelaxing) effects to reduce intestinal cramping. Ginger is approved by the German Commission E for dyspepsia.30,41,51,52,54,55,57 

Hemicellulase is an enzyme that breaks down hemicellulose carbohydrates, the indigestible plant fibers in fruits, vegetables, cereal grains and leguminous seeds. These dietary fibers are not digested in the stomach or small intestine, but instead are fermented in the colon by microbes and/or excreted in bowel movements. Since plant fiber is an important dietary component in the prevention of cardiovascular disease, diabetes and obesity, hemicellulase supplementation is recommended for those who have difficulty digesting fiberrich foods.18,58 

Betaglucanase is an enzyme that breaks down carbohydrates found in cereal grains such as barley, oats, rye and wheat. This digestive enzyme is especially helpful for those who have trouble digesting grainbased food products.18,59 

Phytase is an enzyme that breaks down carbohydrates, particularly phytic acid (phytate), found in seeds, grains and plant leaves. Phytase also helps promote mineral absorption by freeing minerals such as iron, which are bound in phytate.3,18,60-62 

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