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Skeletal Strength is designed to nutritionally support the skeletal system and help maintain healthy bones and structural integrity. Skeletal Strength contains vitamins, minerals and herbs that have been shown to promote bone mineralization and inhibit bone loss. Skeletal Strength also provides digestive aids to ensure absorption of nutrients that are vital for bone health. Skeletal Strength contains:
Vitamin A is an essential nutrient that maintains healthy vision, provides antioxidant protection and immune system support, and plays a crucial role in bone formation. 14
Vitamin C is essential for human life because the body cannot create it, nor does it store it. Vitamin C deficiency is associated with low bone mass and an elevated risk of bone fracture. 13, 5, 6
Vitamin D3 regulates calcium absorption and bone metabolism. Vitamin D promotes intestinal absorption of calcium and phosphorous and plays a central role in maintaining calcium homeostasis and skeletal integrity. Low blood levels of vitamin D are associated with reduced bone mineral density and are common in women with osteoporosis. 7-10
Vitamin B6 Research suggests that vitamin B6 deficiency may have detrimental effects on bone collagen and thus contribute to impaired bone quality. 11, 12
Vitamin B12 Research indicates that vitamin B12 deficiency, a common health problem among older persons and vegetarians, is associated with increased bone turnover and bone fractures. Increasing vitamin B12 levels has been shown to provide a modest decrease in fracture risk.1316
Calcium is the most plentiful mineral in the body, with about 99% stored in bones and teeth. The importance of calcium for skeletal integrity is well known. Sufficient intake of calcium, together with vitamin D, is recommended for the prevention and treatment of osteoporosis. 2, 3, 9, 17-19
Iron Adequate iron intake is necessary for the healthy development of blood, soft tissue and bones. Recent research has shown that iron deficiency inhibits the activity of human osteoblasts (bone building cells) in vitro. Animal research has also confirmed that iron deficiency anemia demonstrates a significant impact on bone, negatively affecting bone mineralization and increasing bone loss. 2, 3, 9, 20, 21
Phosphorus, the second most abundant mineral in the body following calcium, is primarily stored in the bone and is essential for bone health. Phosphorus regulates bone formation and inhibits bone resorption (bone loss); thus, phosphorus deficiency can impair bone health. 22-25
Magnesium is an essential component in the formation of bone and protein, with nearly 70% of the body’s supply of magnesium found in the bones. Adequate magnesium intake is necessary for bone cell activity and skeletal integrity, as magnesium status is related to whole body bone density. Epidemiologic studies have shown that magnesium deficiency accelerates bone turnover and is a risk factor for osteoporosis. 1, 2, 9, 26-30
Zinc is necessary for optimal development of bone matrix and sustaining bone density. The bone matrix is a collagen based foundation on which bones are built, which promotes bone strength and resistance to fractures. Zinc has been shown to stimulate the activity of osteoblasts and inhibit bone resorption, thus suggesting its therapeutic value in the prevention of osteoporosis. 3, 9, 31-34
Copper is a trace mineral needed to build elastin and collagen—important components of bone and connective tissue. Copper may help protect against bone loss and the development of osteoporosis, as subclinical copper deficiency appears to be a contributing factor to bone loss in the elderly. 2, 3, 9, 31, 35, 36
Manganese, a trace mineral found primarily in the bones, plays a role in the synthesis and repair of connective tissue and bones. Manganese deficiency has been shown to disrupt the action of enzymes and hormones involved in bone metabolism and appears to be associated with decreases in bone mass. 2, 3, 31, 37-39
Potassium plays a role in bone health through its ability to neutralize bone depleting metabolic acids and reduce urinary calcium loss. Current evidence from a variety of observational, clinical and intervention studies suggests a positive association between a potassium rich diet and skeletal health and osteoporosis prevention, particularly among the elderly. 13, 40-43
Boron, a trace mineral, participates in calcium metabolism and bone growth and maintenance. Animal studies have confirmed that boron intake has a positive effect on bone strength and bone mineral composition. 44-46
Horsetail is a rich source of calcium and other bone building minerals, including iron, magnesium, manganese, phosphorous, potassium, silica and zinc. As a result, horsetail is often used to help strengthen the skeletal system and facilitate the healing of broken bones and damaged connective tissue. Recent in vitro studies suggest that horsetail can inhibit the formation of osteoclasts (cells that break down bone tissue). 47-51
Betaine HCl facilitates the digestion of protein and may also enhance the absorption of calcium. Research suggests that insufficient stomach acidity can lead to malabsorption of dietary calcium and impaired bone health. 52-55
Papaya contains enzymes that break down protein, fats, carbohydrates, and even milk protein. In addition, papaya is a rich source of vitamin C and potassium, and has been shown to enhance the absorption of iron in food. 47, 52, 56
Parsley contains many vitamins and minerals, including calcium and iron. Animal studies suggest that parsley may help inhibit bone resorption. 47, 48, 57
Pineapple is a natural source of bromelain, a protein digesting enzyme that may also be beneficial in the treatment of osteoarthritis. Pineapple contains significant amounts of vitamins A and C, and has been shown to have a mild to moderate enhancing effect on the absorption of iron in food. 47, 49, 52, 56, 58
Valerian is regarded as an effective antispasmodic (muscle relaxant), mild analgesic (pain reliever) and sedative. Valerian is commonly used for anxiety and stress related conditions, insomnia, migraine/tension headaches, intestinal spasms and muscle cramps. Valerian is also a rich source of calcium and magnesium. 47, 48, 59-61
Licorice contains a natural flavonoid that have been shown to suppress the formation of osteoclasts and prevent inflammatory bone loss in mice. Another licorice flavonoid, glabridin, has been shown to inhibit osteoclast formation, as well as prevent damage to osteoblasts. 62-65
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1Pizzorno, J & Murray, M. A Textbook of Natural Medicine, 2nd Ed. London: Churchill Livingstone, 1999.
2Dunne, L.J. Nutrition Almanac, 3rd Ed. NY, NY: McGrawHill Publishing Co.; 1990.
3Lieberman PhD, S. & Bruning, N. The Real Vitamin & Mineral Book, 2nd Ed. Avery; 1997.
4Tanaka K, et. al. “Deficiency of vitamin A delays bone healing process in association with reduced BMP2 expression after drillhole injury in mice.” Bone; 2010, 47(6):100612.
5Zhu, L.L., et. al. “Vitamin C prevents hypogonadal bone loss.” PLoS One; 2012, 7(10):e47058. Epub 2012, Oct 8.
66Park, J.K., et. al. “Vitamin C deficiency accelerates bone loss inducing an increase in PPARgamma expression in SMP30 knockout mice.” International Journal of Experimental Pathology; 2012, 93(5):332340.
7Cashman, K.D. “Calcium and vitamin D.” Novartis Foundation Symposium; 2007, 282:123138.
8Holick, M.F. “Vitamin D deficiency.” The New England Journal of Medicine; 2007, 357(3):266281.
9Zofková, I., et. al. “Trace elements and bone health.” Clinical Chemistry and Laboratory Medicine; 2013, Mar 18:17.
[Epub ahead of print]
100Wöfl, C., et. al. “Time course of 25(OH)D3 vitamin D3 as well as PTH (parathyroid hormone) during fracture healing of patients with normal and low bone mineral density (BMD).” BMC Musculoskeletal Disorders; 2013, 14:6.
11Saito, M. [Elevated plasma concentration of homocysteine, low level of vitamin B6, pyridoxal, and vitamin D insufficiency in patients with hip fracture: a possible explanation for detrimental crosslink pattern in bone collagen]. Clinical Calcium; 2006, 16(12):19741984.
12Baines, M., et. al. “The association of homocysteine and its determinants MTHFR genotype, folate, vitamin B12 and vitamin B6 with bone mineral density in postmenopausal British women.” Bone; 2007, 40(3):730736.
13Herrmann, W., et. al. “Enhanced bone metabolism in vegetarians the role of vitamin B12 deficiency.” Clinical Chemistry and Laboratory Medicine; 2009, 47(11):13811387.
14Chatthanawaree, W. “Biomarkers of cobalamin (vitamin B12) deficiency and its application.” The Journal of Nutrition, Health and Aging; 2011, 15(3):227231.
15van Wijngaarden, J.P., et. al. “Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B12 and folic acid on fracture incidence.” BMC Geriatrics; 2011, 11:80.
16—. “Vitamin B12, folate, homocysteine, and bone health in adults and elderly people: a systematic review with meta-analyses.” Journal of Nutrition and Metabolism; 2013:486186. Epub 2013, Feb 20.
17Garriguet, D. “Bone health: osteoporosis, calcium and vitamin D.” Health Reports; 2011, 22(3):714.
18Burckhardt, P. [Calcium and Vitamin D in the treatment and prevention of osteoporosis: the actual dilemma]. Therapeutische Umschau; 2012, 69(3):153161.
19Peterlik, M., et. al. “Calcium nutrition and extracellular calcium sensing: relevance for the pathogenesis of osteoporosis,
cancer and cardiovascular diseases.” Nutrients; 2013, 22;5(1):302327.
20Zhao, G.Y., et. al. A comparison of the biological activities of human osteoblast hFOB1.19 between iron excess and iron deficiency.” Biological Trace Element Research; 2012, 150(13): 487495.
21DíazCastro, J., et. al. “Severe nutritional iron deficiency anaemia has a negative effect on some bone turnover biomarkers in rats.” European Journal of Nutrition; 2012, 51(2):241247.
22Yano, S., Sugimoto, T. [Clinical aspect of recent progress in phosphate metabolism. Distribution of phosphorus and its physiological roles in the body: the form, distribution, and physiological function]. Clinical Calcium; 2009, 19(6):771776.
23Ito, S., et. al. The relationship between habitual dietary phosphorus and calcium intake, and bone mineral density in young Japanese women: a cross-sectional study.” Asia Pacific Journal of Clinical Nutrition; 2011, 20(3):411417.
24Kawaura, A., et. al. [Phosphorus intake and bone mineral density (BMD)]. Clinical Calcium; 2005, 15(9):15011506.
25Takeda, E., et. al. “Dietary phosphorus in bone health and quality of life.” Nutrition Reviews; 2012, 70(6):31121.
26Ishii, A., Imanishi Y. [Magnesium disorder in metabolic bone diseases]. Clinical Calcium; 2012, 22(8):12511256. 27Yamamoto, S., Uenishi, K. [Nutrition and bone health. Magnesium rich foods and bone health]. Clinical Calcium; 2010, 20(5):768774.
28Leidi, M., et. al. “Nitric oxide mediates low magnesium inhibition of osteoblast-like cell proliferation.” The Journal of Nutritional Biochemistry; 2012, 23(10):12241229.
29Takaishi, Y. [Significance of the Magnesium in the hard tissues such as Bone and Teeth]. Clinical Calcium; 2012, 22(8):11891196.
30Belluci, M.M., et. al. “Magnesium deficiency results in an increased formation of osteoclasts.” The Journal of Nutritional Biochemistry; 2013, Mar 18. [Epub ahead of print]
31Bergner, P. The Healing Power of Minerals, Special Nutrients and Trace Elements. Prima Publishing, 1997.
32Yamaguchi, M. “Role of nutritional zinc in the prevention of osteoporosis.” Molecular and Cellular Biochemistry; 2010, 338(12): 241254.
33Ovesen, J., et. al. “Differences in zinc status between patients with osteoarthritis and osteoporosis.” Journal of Trace
Elements in Medicine and Biology; 2009, 23(1):18.
34Nielsen, F.H., et. al. “Reported zinc, but not copper, intakes influence whole body bone density, mineral content and T score responses to zinc and copper supplementation in healthy postmenopausal women.” The British Journal of Nutrition; 2011, 106(12):18721879.
35DiSilvestro, R.A., et. al. “A pilot study of copper supplementation effects on plasma F2alpha isoprostanes and urinary collagen crosslinks in young adult women.” Journal of Trace Elements in Medicine and Biology; 2010, 24(3):165168.
36Klevay LM. “Is the Western diet adequate in copper?” Journal of Trace Elements in Medicine and Biology; 2011, 25(4):204212.
37BrodziakDopierala, B., et. al. “The content of manganese and iron in hip joint tissue.” Journal of Trace Elements in Medicine and Biology; 2013, Feb 14. [Epub ahead of print]
38GonzálezPérez, J.M., et. al. “Relative and combined effects of ethanol and protein deficiency on bone manganese and
copper.” Biological Trace Element Research; 2012, 147(13): 226232.
39Zhaojun, W., et. al. “Effects of manganese deficiency on serum hormones and biochemical markers of bone metabolism in chicks.” Journal of Bone and Mineral Metabolism; 2013, Feb 14. [Epub ahead of print]
40Brown, S.E. “Nutrition & Bone Health.” The Center For Better Bones; 2013. <http://tinyurl.com/ccpc2lr>. Accessed March
41LanhamNew, S.A. “The balance of bone health: tipping the scales in favor of potassium rich, bicarbonate-rich foods.” The Journal of Nutrition; 2008, 138(1):172S177S.
42Jehle, S., et. al. “Effect of potassium citrate on bone density, microarchitecture, and fracture risk in healthy older adults without osteoporosis: a randomized controlled trial.” The Journal of Clinical Endocrinology and Metabolism; 2013, 98(1):207217.
43Moseley, K.F., et. al. “Potassium citrate supplementation results in sustained improvement in calcium balance in older men and women.” Journal of Bone and Mineral Research; 2013, 28(3):497504.
44Hunt, C.D. “Dietary boron: progress in establishing essential roles in human physiology.” Journal of Trace Elements in Medicine and Biology; 2012, 26(23): 157160.
45Ying, X., et. al. “Effect of boron on osteogenic differentiation of human bone marrow stromal cells.” Biological Trace Element Research; 2011, 144(13): 306315.
46Hakki, S.S., et. al. “Boron enhances strength and alters mineral composition of bone in rabbits fed a high energy diet.” Journal of Trace Elements in Medicine and Biology; 2013, 27(2):148153.
47Fetrow, C. & Avila, J. Professional’s Handbook of Complementary & Alternative Medicines. Springhouse, 1999.
48Herbal Medicine: Expanded Commission E Monographs. Newton, MA: Integrative Medicine, 2000.
49Chevallier, A. The Encyclopedia of Medicinal Plants. NY, NY: Dorling Kindersley Inc., 1996.
50Sapei, L., et. al. “Structural and analytical studies of silica accumulations in Equisetum hyemale.” Analytical and Bioanalytical Chemistry; 2007, 389(4):12491257.
51CostaRodrigues, J., et. al. “Inhibition of human in vitro osteoclastogenesis by Equisetum arvense.” Cell Proliferation; 2012, 45(6):566576.
52Cichoke DC, A. Enzymes & Enzyme Therapy, 2nd Ed. Los Angeles, CA: Keats, 2000.
53Chu, S., Schubert, M.L. “Gastric secretion.” Current Opinion in Gastroenterology; 2012, 28(6):587593.
54Kopic, S., Geibel, J.P. “Gastric acid, calcium absorption, and their impact on bone health.” Physiological Reviews; 2013, 93(1):189268.
55Sipponen, P., Härkönen, M. “Hypochlorhydric stomach: a risk condition for calcium malabsorption and osteoporosis?” Scandinavian Journal of Gastroenterology; 2010;45(2):133138.
56Ballot, D., et. al. “The effects of fruit juices and fruits on the absorption of iron from a rice meal.” The British Journal of Nutrition; 1987, 57(3):331343.
57Putnam, S.E., et. al. “Natural products as alternative treatments for metabolic bone disorders and for maintenance of bone health.” Phytotherapy Research; 2007, 21(2):99112.
58Pavan, R., et. al. “Properties and therapeutic application of bromelain: a review.” Biotechnology Research International; 2012, 2012:976203. Epub 2012, Dec 10.
59Presser PharmD, A. Pharmacist’s Guide to Medicinal Herbs. Petaluma, CA: Smart Publications, 2000.
60Mirabe, P., et. al. "Effects of Valeriana Officinalis on the Severity of Dysmenorrheal Symptoms.“ Journal of Reproduction & Infertility; 2010, 10(4):330.
61Duke PhD, J. Dr. Duke’s Phytochemical and Ethnobotanical Databases. <http://tinyurl.com/2egkh6f>. Accessed February 2013.
62Zhu, L., et. al. “Licorice isoliquiritigenin suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo.” The International Journal of Biochemistry & Cell Biology; 2012, 44(7):11391152.
63Kim, H.S., et. al. “The flavonoid glabridin attenuates 2deoxyDriboseinduced oxidative damage and cellular dysfunction in MC3T3E1 osteoblastic cells.” International Journal of Molecular Medicine; 2013, 31(1):243251.
64—. “The inhibitory effect and the molecular mechanism of glabridin on RANKL-induced osteoclastogenesis in RAW264.7 cells.” International Journal of Molecular Medicine; 2012, 29(2):169177.
65Choi, E.M. “Glabridin protects osteoblastic MC3T3E1 cells against anti-mycin A induced cytotoxicity.” Chemico-Biological Interactions; 2011, 193(1):7178.
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