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Research shows that memory function typically declines with age, even in healthy adults. Fortunately, studies suggest that dietary factors may reduce the symptoms of age-related cognitive impairment.1-6 

Mind-Max is a nutritional supplement designed to support brain function by providing herbs and nutrients that have been shown to enhance memory and improve cognitive performance, as well as reduce anxiety. Mind-Max contains: 

Magnesium L-threonate - Magnesium is essential for the healthy functioning of the brain and other body functions. Magnesium is primarily derived from green leafy vegetables and unprocessed grains. Unfortunately, given modern dietary practices, inadequate magnesium levels are quite common, affecting 50% or more of the U.S. population. Research shows that magnesium deficiency is associated with aging, as well as the increased incidence of many chronic diseases, including age-related memory decline and neurodegenerative disorders—debilitating conditions primarily affecting the neurons in the human brain. For example, studies have shown that patients with Alzheimer’s disease exhibit decreased brain magnesium levels. Furthermore, evidence suggests that brain magnesium levels correlate with anxietyrelated behavior, as well as treatment-resistant depression.3,6-15 

Recently, neuroscientists at the Massachusetts Institute of Technology (MIT) and Tsinghua University in Beijing, China developed a new magnesium compound, magnesium-L-threonate (MgT), which has been shown to increase brain magnesium levels in animal studies. Unlike traditional magnesium supplements, MgT was shown to significantly raise brain magnesium levels in mice and 

enhance learning abilities and short- and long-term memory in both young and old rats alike. In addition, MgT treatment effectively prevented learning impairment and memory deterioration in Alzheimer’s diseased mice during the entire course of the disease progression—without treatment, learning and memory abilities completely deteriorate within 15 months. Based on these preliminary findings, along with previous research that supports magnesium supplementation as a potential therapeutic strategy for preventing Alzheimer’s disease, MgT may prove to enhance memory and cognitive function in humans. Furthermore, given the results of animal studies, MgT may also prove beneficial in the treatment of anxiety, phobias and posttraumatic stress disorder (PTSD)-like behavior in humans.3,7,11-13,15-19 

Gotu Kola (Centella asiatica) has been used for centuries in traditional Ayurvedic and Chinese medicine for its intelligence-promoting and memory-enhancing properties. Gotu kola’s cognitive effects are recognized by the World Health Organization and the Commission E of the German Ministry of Health. Animal studies have confirmed gotu kola’s effects on memory, learning, aging and its potential use in Alzheimer's disease. Human studies have revealed multiple beneficial clinical effects of gotu kola, particularly regarding age-related cognitive decline. Gotu kola has been shown to revitalize the brain and nervous system, increase attention span and concentration, and combat aging. Human clinical studies have demonstrated significant cognitive improvements in elderly patients with mild cognitive impairment. In addition, gotu kola has exhibited anxiolytic (anti-anxiety) activity in humans, as well as positive effects in the treatment of depression and stress-related disorders.20-25 

Bacopa monniera has been used in Ayurvedic medicine for centuries for improving memory, enhancing learning and treating mental disorders. Double-blind, randomized, placebo-controlled studies have confirmed that bacopa provides memory-enhancing effects and exhibits the potential for improving cognitive performance in the elderly, including memory acquisition and retention, alertness, concentration, comprehension and recall. Bacopa has also demonstrated anxiolytic and anti-depressant activity and has been shown to reduce depression and anxiety in both animals and humans.2,23,26,27 

Ginkgo (Ginkgo biloba) is likely the most widely used herbal medicine in the United States and Europe for alleviating symptoms of age-related cognitive decline and dementia. Ginkgo biloba leaf extract has been shown to enhance working memory and mental performance in both healthy young individuals and patients with age-related cognitive impairment. Research suggests that ginkgo biloba may improve cognitive processes and memory deficits through its numerous vascular effects, as well as by influencing various neurotransmitter systems that are of critical importance in cognition. In addition, ginkgo biloba demonstrates anxiolytic and anti-depressant effects. Human studies have demonstrated that ginkgo biloba can reduce anxiety, elevate mood and enhance quality of life in patients with anxiety disorders and mild-tomoderate dementia.28-38 

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1Nyberg, L, et. al. “Memory aging and brain maintenance.” Trends in Cognitive Sciences; 2012, 16(5):292-305. 

2Calabrese, C., et. al. “Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial.” Journal of Alternative and Complementary Medicine; 2008, 14(6):707-713. 

3Liu, G. “Prevention of cognitive deficits in Alzheimer’s mouse model by elevating brain magnesium.” Molecular Neurodegeneration; 2012, 7(Suppl 1): L24. [Epub ahead of print] 

4Bourre, J.M. “Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 1: micronutrients.” The Journal of Nutrition, Health & Aging; 2006, 10(5):377-385. 

5Wengreen, H.J., et. al. “Diet quality is associated with better cognitive test performance among aging men and women.” The Journal of Nutrition; 2009, 139(10):1944-1949. 

6Killilea, D.W., Maier, J.A. “A connection between magnesium deficiency and aging: new insights from cellular studies.” Magnesium Research; 2008, 21(2):77-82. 

7Cheung, F. “Neuropharmacology: Magnesium is the new brain food.” Nature China; February 10, 2010. 

<http://tinyurl.com/c5jsble>. Accessed May 2012. 

8Killilea, D.W., Ames, B.N. “Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts.” Proceedings of the National Academy of Sciences of the United States of America; 2008, 105(15):5768-5773. 

9Rowe, W.J. “Correcting magnesium deficiencies may prolong life.” Clinical Interventions in Aging; 2012, 7:51-54. 

10Barbagallo, M., et. al. “Altered ionized magnesium levels in mild-to-moderate Alzheimer's disease.” Magnesium Research; 2011, 24(3):S115-121. 

11Billard, J.M. “Ageing, hippocampal synaptic activity and magnesium.” Magnesium Research; 2006, 19(3):199-215. 

12Yu, J., et. al. “Magnesium modulates amyloid-beta protein precursor trafficking and processing.” Journal of Alzheimer’s Disease; 2010, 20(4):1091-1106. 

13Laarakker, M.C., et. al. “Behavioral characterization of A/J and C57BL/6J mice using a multidimensional test: association between blood plasma and brain magnesium-ion concentration with anxiety.” Physiology & Behavior; 2011, 102(2):205-219. 

14Eby, G.A. 3rd, Eby, K.L. “Magnesium for treatment-resistant depression: a review and hypothesis.” Medical Hypotheses; 2010, 74(4):649-660. 

15Socala, K., et. al. “Influence of the phosphodiesterase type 5 inhibitor, sildenafil, on antidepressant-like activity of magnesium in the forced swim test in mice.” Pharmacological Reports; 2012, 64(1):205-211. 

16Slutsky, I., et. al. “Enhancement of learning and memory by elevating brain magnesium.” Neuron; 2010, 65(2):165-177. 

17“Magnesium Supplement Helps Boost Brainpower.” Science Daily; Jan. 27, 2010. <http://tinyurl.com/yexp76c>. Accessed May 2012. 

18Siener, R., et. al. “Bioavailability of magnesium from different pharmaceutical formulations.” Urological Research; 2011, 39(2):123-127. 

19Abumaria, N., et. al. “Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala.” The Journal of Neuroscience; 2011, 31(42):14871-14881. 

20Orhan, I.E. “Centella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential.” Evidence-Based Complementary and Alternative Medicine. 2012; 2012:946259. Epub 2012 May 14. 

21Gohil, K.J., et. al. “Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all.” Indian Journal of Pharmaceutical Sciences; 2010, 72(5):546-556. 

22Soumyanath, A., et. al. Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action.” International Journal of Alzheimer’s Disease; 2012, 2012:381974. Epub 2012 Feb 15. 

23Meena, H., et. al. “Evaluation of antioxidant activity of two important memory enhancing medicinal plants Baccopa monnieri and Centella asiatica.” Indian Journal of Pharmacology; 2012, 44(1):114-117. 

24Wattanathorn, J., et. al. “Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica.” Journal of Ethnopharmacology; 2008, 116(2):325-32. 

25Jana, U., et. al. “A clinical study on the management of generalized anxiety disorder with Centella asiatica.” Nepal Medical College Journal; 2010, 12(1):8-11. 

26Morgan, A., Stevens, J. “Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial.” Journal of Alternative and Complementarty Medicine; 2010, 16(7):753-759. 

27Mathew, J., et. al. “Bacopa monnieri and Bacoside-A for ameliorating epilepsy associated behavioral deficits.” Fitoterapia;2010, 81(5):315-322. 

28Snitz, B.E., et. al. “Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial.” The Journal of the American Medical Association; 2009, 302(24):2663-2670. 

29Silberstein, R.B., et. al. “Examining brain-cognition effects of ginkgo biloba extract: brain activation in the left temporal and left prefrontal cortex in an object working memory task.” Evidence-Based Complementary and Alternative Medicine. 2011; 2011:164139. Epub 2011 Aug 18. 

30Weinmann, S., et. al. “Effects of Ginkgo biloba in dementia: systematic review and meta-analysis.” BMC Geriatrics; 2010, 10:14. 

31Kaschel, R. “Specific memory effects of Ginkgo biloba extract EGb 761 in middle-aged healthy volunteers.” Phytomedicine; 2011, 18(14):1202-1207. 

32Attia, A., et. al. “Phase II study of Ginkgo biloba in irradiated brain tumor patients: effect on cognitive function, quality of life, and mood.” Journal of Neurooncology; 2012 Jun 15. [Epub ahead of print] 

33Birks, J., Grimley Evans, J. “Ginkgo biloba for cognitive impairment and dementia.” Cochrane Database of Systematic Reviews; 2009, Jan 21;(1):CD003120. 

34Sarris, J., et. al. “Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence.” European Neuropsychopharmacology; 2011, 21(12):841-860. 

35Faustino, T.T., et. al. [Medicinal plants for the treatment of generalized anxiety disorder: a review of controlled clinical studies]. Revista Brasileira de Psiquiatria; 2010, 32(4):429-436. 

36Bachinskaya, N., et. al. “Alleviating neuropsychiatric symptoms in dementia: the effects of Ginkgo biloba extract EGb 761. Findings from a randomized controlled trial.” Neuropsychiatric Disease and Treatment; 2011, 7:209-215. 

37Gorby, H.E., et. al. “Do specific dietary constituents and supplements affect mental energy? Review of the evidence.” Nutrition Reviews; 2010, 68(12):697-718. 

38Herrschaft, H., et. al. “Ginkgo biloba extract EGb 761(®) in dementia with neuropsychiatric features: A randomised, placebocontrolledtrial to confirm the efficacy and safety of a daily dose of 240 mg.” Journal of Psychiatric Research; 2012, 46(6):716 

This information is provided by HerbsReallyWork.com 

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The information on this website is intended for educational and research purposes only. No information is intended to prescribe medication or practice medicine, nor is it intended to prevent, treat or cure symptoms, conditions or diseases. Unless otherwise noted, no statements are approved by the FDA. This information is not supplied by or endorsed by Nature's Sunshine Products, Inc. 


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